Daily Archives: October 6, 2016

How Long Does THC Stay in Your System? | Leafly

a 1989 study of chronic users showed a maximum detection window of 25 days at a sensitivity of 20 ng/mL. Yet he points out that only one subject tested positive after 14 days, and it took an average of just 9.8 days before cannabinoid levels were no longer detectible. And while a 1984 study testing… Read More »

Evidence for a limit to human lifespan : Nature : Nature Research

Driven by technological progress, human life expectancy has increased greatly since the nineteenth century. Demographic evidence has revealed an ongoing reduction in old-age mortality and a rise of the maximum age at death, which may gradually extend human longevity. Together with observations that lifespan in various animal species is flexible and can be increased by… Read More »

BioDiscovery Skeletal muscle: novel and intriguing characteristics as a secretory organ

Skeletal muscle secretes several bioactive proteins from within the cell into extracellular fluid. The secretion of several proteins, whose levels increase in response to exercise, can mediate exercise-induced benefits such as metabolic improvement, anti-inflammation, and muscle hypertrophy. We recently found a novel muscle-secreted protein SPARC which may be fundamental for the colon cancer prevention mechanism… Read More »

Frontiers | Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling | Frontiers in Cellular Neuroscience

Putative Effects of Extreme Physical Activity on the Brain and Cognitive FunctionDespite the positive effects of moderate physical activity on the brain, a number of studies have linked extreme exercise to disruption of cellular, metabolic, and hormonal processes and, in turn, to adverse neurological sequelae and cognitive dysfunction. Here, we review cellular mechanisms by which… Read More »

Frontiers | Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling | Frontiers in Cellular Neuroscience

Figure 4. Schematic representation of mechanisms by which increased physical activity leads to improved cognitive function. The figure depicts the two compartments alongside the blood brain barrier and the bidirectional relationship of BNDF between central and peripheral compartments. For instance, muscles, liver, and immune cells in the periphery impose a significant influence on the brain,… Read More »

Frontiers | Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling | Frontiers in Cellular Neuroscience

BDNF is synthesized in the periphery by vascular endothelial cells, T-cells, B cells, monocytes (Kerschensteiner et al., 1999; Nakahashi et al., 2000) and skeletal muscles (Mousavi and Jasmin, 2006). Once released, BDNF can cross the BBB bi-directionally (Pan et al., 1998), resulting in a direct relationship between BDNF levels in plasma and the brain (Karege… Read More »