Daily Archives: August 28, 2015

Reversal of learned helplessness by selective serotonin reuptake inhibitors in rats is not dependent on 5-HT availability Arturo Zazpe, Inés Artaiz, Luis Labeaga, María Luisa Lucero, Aurelio Orjales, Serotonin (5-HT) and 5-HT1A receptors have been suggested to play a pivotal role in the mechanism of action of antidepressant drugs, particularly in the case of selective… Read More »

Reversal of Learned Helplessness by Morphine in Rats ☆: Involvement of a Dopamine Mediation A. Besson*, A.M. Privat*, A. Eschalier†, J. Fialip*, The aim of this study was to examine the role of dopamine neurotransmission in the effects of morphine in the learned helplessness paradigm in rats, a generally recognized model of depression. In this… Read More »

Pharmacology Biochemistry and BehaviorVolume 17, Issue 5, November 1982, Pages 877-883Cover imageEvidence for a serotonergic mechanism of the learned helplessness phenomenon Loren Brown, Robert A. Rosellini, Owen B. Samuels, Edward P. Riley S The present experiments examined the role of the serotonergic system in the learned helplessness phenomenon. In Experiment 1, a 200 mg/kg dose… Read More »