New studies link brain inflammation and preeclampsia with increased autism risk – Los Angeles LA | Examiner.com
SO; Is a lack of cock sucking now child abuse?
The likelihood of developing autism and developmental delay was doubled in the mothers who experienced preeclampsia compared to the control group. The scientists determined that this could be attributed to enhanced systemic inflammation as a result of preeclampsia, leading to a restriction of the amount of nutrients and oxygen being transferred to the placenta, and restricted levels of growth and oxygenated blood in the fetus.
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STRAIGHT FROM THE NATIONAL INSTITUTE OF HEALTH WEB SITE:
r;46(2):155-66.
Correlation between oral sex and a low incidence of preeclampsia: a role for soluble HLA in seminal fluid?
Abstract
The involvement of immune mechanisms in the aetiology of preeclampsia is often suggested. Normal pregnancy is thought to be associated with a state of tolerance to the foreign antigens of the fetus, whereas in preeclamptic women this immunological tolerance might be hampered. The present study shows that oral sex and swallowing sperm is correlated with a diminished occurrence of preeclampsia which fits in the existing idea that a paternal factor is involved in the occurrence of preeclampsia. Because pregnancy has many similarities with transplantation, we hypothesize that induction of allogeneic tolerance to the paternal HLA molecules of the fetus may be crucial. Recent data suggest that exposure, and especially oral exposure to soluble HLA (sHLA) or HLA derived peptides can lead to transplantation tolerance. Similarly, sHLA antigens, that are present in the seminal plasma, might cause tolerance in the mother to paternal antigens. In order to test whether this indeed may be the case, we investigated whether sHLA antigens are present in seminal plasma. Using a specific ELISA we detected sHLA class I molecules in seminal plasma. The level varied between individuals and was related to the level in plasma. Further studies showed that these sHLA class I molecules included classical HLA class I alleles, such as sHLA-A2, -B7, -B51, -B35 and sHLA-A9. Preliminary data show lower levels of sHLA in seminal plasma in the preeclampsia group, although not significantly different from the control group. An extension of the present study is necessary to verify this hypothesis.
NOW BACK TO THE NEWS
Two new studies published this week link various risk factors with the development of autism. The first study published Wednesday in the journal Nature Communications analyzed 104 samples of brain tissue in 72 individuals, 32 of whom were diagnosed with autism spectrum disorder (ASD), the largest sample thus far in a study of its kind. The researchers sought to analyze the gene expression of support cells in the brain tissues, referred to as microglia, and found that the genes that controlled for brain inflammation were permanently activated in the brains of those with autism.
While the scientists were quick to point out that it’s unlikely that this inflammation is the root cause of autism, it may be a consequence of other genetic mutation and abnormalities. This inflammatory response may be indicative of the overactive immune response seen in previous studies that analyzed possible contributors to the development of autism. Down the line, pursuing treatments for this response may lead to an amelioration of autism symptoms.
The second study published Monday in the journal JAMA Pediatrics looked at risk factors during pregnancy that may contribute to the onset of ASD. Researchers looked at 1,000 children with autism or developmental delay born to mothers who experienced preeclampsia, a condition during the second or third trimester of pregnancy in which the mother develops high blood pressure, vision problems, kidney dysfunction and other inflammatory responses, affecting between 2-8% of pregnancies worldwide.
They found that the likelihood of developing autism and developmental delay was doubled in the mothers who experienced preeclampsia compared to the control group. The scientists determined that this could be attributed to enhanced systemic inflammation as a result of preeclampsia, leading to a restriction of the amount of nutrients and oxygen being transferred to the placenta, and restricted levels of growth and oxygenated blood in the fetus. While there is no current definitive method of prevention, current medical research points to the importance of prenatal and maternal health as preventative measures for the condition.
SO NOW YOU KNOW. THOSE COUPLES WITH AN AUTISTIC KID HAVE A PRUDISH SELFISH CAUSE