Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study ( Gomes et al., 2013 ) shows that reduced levels of nicotinamide adenine dinucleotide (NAD+) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.
NAD+ Deficiency in Age-Related Mitochondrial Dysfunction: Cell Metabolism.