Daily Archives: November 13, 2014

Mitochondria & aging: ‘Remarkable’ effects for nicotinamide riboside in mice, says new study

Niagen N(R) from HPN In the supplement space, nicotinamide riboside is commercialized by Chromadex, which has been accumulating the IP surrounding the ingredient for a couple of years, having licensed patents from Cornell University, Dartmouth College, and Washington University in St Louis. via Mitochondria & aging: ‘Remarkable’ effects for nicotinamide riboside in mice, says new… Read More »

NAD+ Deficiency in Age-Related Mitochondrial Dysfunction: Cell Metabolism

Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study ( Gomes et al., 2013 ) shows that reduced levels of nicotinamide adenine dinucleotide (NAD+) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.… Read More »

ACUTE EFFECT OF ALCOHOL ON ANDROGENS IN PREMENOPAUSAL WOMEN | Alcohol and Alcoholism

Heavy alcohol consumption is associated with abnormalities of the menstrual cycle, sterility, miscarriages, and loss of female sexual characteristics, all of which are affected by the hormonal balance in women (Van Thiel and Lester, 1979). Thus, it seems reasonable to postulate that these adverse effects could at least in part originate from alcohol-mediated changes in… Read More »

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition – Annual Review of Nutrition, 28(1):115

Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas for future research. via Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition – Annual Review of Nutrition, 28(1):115.

NAD and live forever

Scientific Studies Mitochondrial Function [1.] Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38.… Read More »