Archive for November, 2014
N(R) from HPN
In the supplement space, nicotinamide riboside is commercialized by Chromadex, which has been accumulating the IP surrounding the ingredient for a couple of years, having licensed patents from Cornell University, Dartmouth College, and Washington University in St Louis.
Niagen and the IP on it
Mitochondria & aging: ‘Remarkable’ effects for nicotinamide riboside in mice, says new study
By Stephen Daniells+, 15-Jul-2014
Nicotinamide adenine dinucleotide (NAD), is one of two main metabolically active forms of vitamin B-3. The other is NAD phosphate (NADP). NAD is a prominent coenzyme in the brain, where it helps to generate the massive energy that the brain requires for its normal function. NAD is necessary for many stages of converting food into energy and in alcohol metabolism.
The Benefits of Coenzymated Sublingual Vitamins
In order for vitamins to be utilized by the body, they must first be converted into their active coenzyme forms. Source Naturals Coenzymated B-3 goes directly into your bloodstream in its active form, ready to go to work immediately. This avoids the loss that may occur not only during digestion, but during the liver’s conversion process as well.
Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study ( Gomes et al., 2013 ) shows that reduced levels of nicotinamide adenine dinucleotide (NAD+) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.
Heavy alcohol consumption is associated with abnormalities of the menstrual cycle, sterility, miscarriages, and loss of female sexual characteristics, all of which are affected by the hormonal balance in women (Van Thiel and Lester, 1979). Thus, it seems reasonable to postulate that these adverse effects could at least in part originate from alcohol-mediated changes in hormone levels.
Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition – Annual Review of Nutrition, 28(1):115Author: SupremePundit
Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas for future research.
[1.] Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38.
[2.] NAD+ and sirtuins in aging and disease. Imai SI, Guarente L. Trends Cell Biol. 2014 Apr 28. pii: S0962-8924(14)00063-4.
[3.] NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease. Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, Leoni V, Schon EA, Dantzer F, Auwerx J, Viscomi C, Zeviani M. Cell Metab. 2014 May 7. pii: S1550-4131(14)00164-8. *
[4.] Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsström S, Pasila L, Velagapudi V, Carroll CJ, Auwerx J, Suomalainen A. EMBO Mol Med. 2014 Apr 6.
[5.] The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. Cell Metab. 2012 Jun 6;15(6):838-47. *
[1.] Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GM. Neurobiol Aging. 2013 Jun;34(6):1581-8. *
[1.] Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. Sasaki Y, Araki T, Milbrandt J. J Neurosci. 2006 Aug 16;26(33):8484-91.
[1.] NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy. Goody MF, Kelly MW, Reynolds CJ, Khalil A, Crawford BD, Henry CA. PLoS Biol. 2012;10(10):e1001409
[1.] Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Yoshino J, Mills KF, Yoon MJ, Imai S. Cell Metab. 2011 Oct 5;14(4):528-36.
[1.] Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae. Lu SP, Kato M, Lin SJ. J Biol Chem. 2009 Jun 19;284(25):17110-9.
[2.] Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C. J Biol Chem. 2009 Jan 2;284(1):158-64.
[3.] Nicotinamide riboside kinase structures reveal new pathways to NAD+. Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C. PLoS Biol. 2007 Oct 2;5(10):e263.
[3.] Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Cell. 2007 May 4;129(3):473-84.
[4.] Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Bieganowski P, Brenner C. Cell. 2004 May 14;117(4):495-502.
[5.] The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J. Cell. 2013 Jul 18;154(2):430-41.
[6.] NAD+ as a signaling molecule modulating metabolism. Cantó C, Auwerx J. Cold Spring Harb Symp Quant Biol. 2011;76:291-8.
[7.] NAD⁺ metabolism: a therapeutic target for age-related metabolic disease.Mouchiroud L, Houtkooper RH, Auwerx J. Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):397-408.
[1.] NAD+ and sirtuins in aging and disease. Imai SI, Guarente L. Trends Cell Biol. 2014 Apr 28. pii: S0962-8924(14)00063-4
[2.] Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Chi Y, Sauve AA. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61
[3.] Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Bogan KL, Brenner C. Annu Rev Nutr. 2008;28:115-30.
[4.] NAD+ and vitamin B3: from metabolism to therapies. Sauve AA. J Pharmacol Exp Ther. 2008 Mar;324(3):883-93.
[5.] NAD+ metabolism in health and disease. Belenky P, Bogan KL, Brenner C. Trends Biochem Sci. 2007 Jan;32(1):12-9. Epub 2006 Dec 11
via Live Cell Research.
MSG – TRESK gene / glutamate
Aged cheeaze, hot dogs, bacon, sausages, = tyramine
Olives, red plums, Avocado = tyramine
Red vinegar = tyramine
bananas = tyramine and histamine
Citrus fruits = tyramine and histamine
Beans = tannins
Peppers = capisiam
Dried fruits = sulfates
Yeast bread = coumarin
whole milk = choline, casein
sour cream, = choline
Chocolate = phenylethylamine, tannin
Artificial sweetners = excitotoxins
– See more at: http://www.healthcentral.com/migraine/cf/slideshows/27-foods-that-can-trigger-migraines?ap=825#slide=5
– See more at: http://www.healthcentral.com/migraine/cf/slideshows/27-foods-that-can-trigger-migraines?ap=825#slide=5
November 9, 2014
The seminars offered police officers some useful tips on seizing property from suspected criminals. Don’t bother with jewelry (too hard to dispose of) and computers (“everybody’s got one already”), the experts counseled. Do go after flat screen TVs, cash and cars. Especially nice cars.
In one seminar, captured on video in September, Harry S. Connelly Jr., the city attorney of Las Cruces, N.M., called them “little goodies.” And then Mr. Connelly described how officers in his jurisdiction could not wait to seize one man’s “exotic vehicle” outside a local bar.
“A guy drives up in a 2008 Mercedes, brand new,” he explained. “Just so beautiful, I mean, the cops were undercover and they were just like ‘Ahhhh.’ And he gets out and he’s just reeking of alcohol. And it’s like, ‘Oh, my goodness, we can hardly wait.’ ”
Mr. Connelly was talking about a practice known as civil asset forfeiture, which allows the government, without ever securing a conviction or even filing a criminal charge, to seize property suspected of having ties to crime. The practice, expanded during the war on drugs in the 1980s, has become a staple of law enforcement agencies because it helps finance their work. It is difficult to tell how much has been seized by state and local law enforcement, but under a Justice Department program, the value of assets seized has ballooned to $4.3 billion in the 2012 fiscal year from $407 million in 2001. Much of that money is shared with local police forces.
The practice of civil forfeiture has come under fire in recent months, amid a spate of negative press reports and growing outrage among civil rights advocates, libertarians and members of Congress who have raised serious questions about the fairness of the practice, which critics say runs roughshod over due process rights. In one oft-cited case, a Philadelphia couple’s home was seized after their son made $40 worth of drug sales on the porch. Despite that opposition, many cities and states are moving to expand civil seizures of cars and other assets. The seminars, some of which were captured on video, raise a curtain on how law enforcement officials view the practice.
From Orange County, N.Y., to Rio Rancho, N.M., forfeiture operations are being established or expanded. In September, Albuquerque, which has long seized the cars of suspected drunken drivers, began taking them from men suspected of trying to pick up prostitutes, landing seven cars during a one-night sting. Arkansas has expanded its seizure law to allow the police to take cash and assets with suspected connections to terrorism, and Illinois moved to make boats fair game under its D.W.I. laws, in addition to cars. In Mercer County, N.J., a prosecutor preaches the “gospel” that forfeiture is not just for drug arrests — cars can be seized in shoplifting and statutory rape cases as well.
“At the grass-roots level — cities, counties — they continue to be interested, perhaps increasingly so, in supplementing their budgets by engaging in the type of seizures that we’ve seen in Philadelphia and elsewhere,” said Lee McGrath, a lawyer for the Institute for Justice, a public interest law firm that has mounted a legal and public relations assault on civil forfeiture.
Much of the nuts-and-bolts how-to of civil forfeiture is passed on in continuing education seminars for local prosecutors and law enforcement officials, some of which have been captured on video. The Institute for Justice, which brought the videos to the attention of The Times, says they show how cynical the practice has become and how profit motives can outweigh public safety.
In the sessions, officials share tips on maximizing profits, defeating the objections of so-called “innocent owners” who were not present when the suspected offense occurred, and keeping the proceeds in the hands of law enforcement and out of general fund budgets. The Times reviewed three sessions, one in Santa Fe, N.M., that took place in September, one in New Jersey that was undated, and one in Georgia in September that was not videotaped.
Officials offered advice on dealing with skeptical judges, mocked Hispanics whose cars were seized, and made comments that, the Institute for Justice said, gave weight to the argument that civil forfeiture encourages decisions based on the value of the assets to be seized rather than public safety. In the Georgia session, the prosecutor leading the talk boasted that he had helped roll back a Republican-led effort to reform civil forfeiture in Georgia, where seized money has been used by the authorities, according to news reports, to pay for sports tickets, office parties, a home security system and a $90,000 sports car.
In defense of the practice, Gary Bergman, a prosecutor with the Prosecuting Attorneys’ Council of Georgia, said civil forfeiture had been distorted in news reports. “All they hear is the woman was left on the side of the road and the police drove off with her car and her money, no connection to drugs,” he told other prosecutors at the session.
“I’m not saying that that doesn’t happen — it does. It should not. But they never hear about all the people that get stopped with the drugs in their cars, in their houses, the manufacturing operations we see, all the useful things we do with the money, the equipment, vehicles. They don’t hear about that.”
In an interview, Mr. Connelly said that the Las Cruces ordinance does only what the State Supreme Court has said is permissible.
Sean D. McMurtry, the chief of the forfeiture unit in the Mercer County, N.J., prosecutor’s office, said forfeiture contributes to only a small percentage of local budgets but it is a good deterrent and works especially well against repeat offenders, such as domestic violence perpetrators who repeatedly violate a restraining order. “We’re very proud of our forfeiture operation,” he said in an interview.
But in the video, Mr. McMurtry made it clear that forfeitures were highly contingent on the needs of law enforcement. In New Jersey, the police and prosecutors are allowed to use cars, cash and other seized goods; the rest must be sold at auction. Cellphones and jewelry, Mr. McMurtry said, are not worth the bother. Flat screen televisions, however, “are very popular with the police departments,” he said.
Prosecutors boasted in the sessions that seizure cases were rarely contested or appealed. But civil forfeiture places the burden on owners, who must pay court fees and legal costs to get their property back. Many seizures go uncontested because the property is not worth the expense.
And often the first hearing is presided over not by a judge but by the prosecutor whose office benefits from the proceeds, and who has wide discretion in deciding whether to forfeit the property or return it, sometimes in exchange for a steep fine.
Mr. McMurtry said his handling of a case is sometimes determined by department wish lists. “If you want the car, and you really want to put it in your fleet, let me know — I’ll fight for it,” Mr. McMurtry said, addressing law enforcement officials on the video. “If you don’t let me know that, I’ll try and resolve it real quick through a settlement and get cash for the car, get the tow fee paid off, get some money for it.”
One criticism of civil forfeiture is that it results in widely varied penalties — one drunken driver could lose a $100,000 luxury car, while another forfeits a $2,000 clunker.
In an interview, Mr. McMurtry acknowledged that he exercises a great deal of discretion. “The first offense, if it’s not anything too serious, we’ll come up with a dollar amount, depending on the value of the car and the seriousness of the offense,” he said. “I try to come up with a dollar amount that’s not so high that they can’t afford it, but not so low that it doesn’t have an impact. If it’s a second offense, they don’t get it back.”
Prosecutors estimated that between 50 to 80 percent of the cars seized were driven by someone other than the owner, which sometimes means a parent or grandparent loses their car. In the Santa Fe video, a police officer acknowledged that the law can affect families, but expressed skepticism of owners who say they did not know their relative was running afoul of the law.
“I can’t tell you how many people have come in and said, ‘Oh, my hijito would never do that,’ ” he said, mimicking a female voice with a Spanish accent.
– – Bonnie Kristian